Attenuated vancomycin bactericidal activity against Staphylococcus aureus hemB mutants expressing the small-colony-variant phenotype.

نویسندگان

  • Brian T Tsuji
  • Christof von Eiff
  • Pamela A Kelchlin
  • Alan Forrest
  • Patrick F Smith
چکیده

The in vitro bactericidal activities of vancomycin against Staphylococcus aureus hemB mutants displaying the small-colony-variant phenotype and their parental strains were evaluated. Vancomycin killing activities against hemB mutants were markedly attenuated, demonstrating approximately 50% less effect, a result which was well described by a Hill-type pharmacodynamic model.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 52 4  شماره 

صفحات  -

تاریخ انتشار 2008